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Endothelial Adora2a activation promotes blood-brain barrier breakdown and cognitive impairment in mice with diet-induced insulin resistance

Zepbound (tirzepatide) is an FDA-approved medication for chronic weight management that works through dual GIP and GLP-1 receptor agonism

Its sequence, His-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Glu-Lys-Lys-Ala-Lys-(AEEA-AEEA--Glu-diacid-C20)-Glu-Phe-Val-Glu-Trp-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-NH shows how its engineered structure makes it more stable and better at binding to receptors

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