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PubMed Dorr RT, Dvorakova K, Brooks C, Lines R, Levine N, et al

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Upon inhalation, PAHs are bioactivated by cytochrome P450 (CYP450) enzymes, converting them into highly reactive electrophiles such as diol-epoxides and redox-active quinones

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Surgical Management and Surgery-Specific Considerations Resectability is strongly related to outcomes, and survival depends upon wide resection [49,50]

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