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Where GLP-1 primarily activates hypothalamic neurons involved in energy balance, amylin targets hindbrain circuits that regulate meal-specific satiety and food reward

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Approximately 70% of the autistic children enrolled in our studies also exhibit comorbid ADHD, making this exploration particularly relevant

This distinguishes retatrutide from GLP-1 receptor agonists such as semaglutide, which primarily target the GLP-1 receptor, and dual agonists such as tirzepatide, which act on GLP-1 and GIP receptors without activating the glucagon receptor.[3] This three-receptor profile is a major reason retatrutide has drawn interest in metabolic research