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The consequences of muscle mass loss during GLP-1-induced weight loss include reduced resting metabolic rate making weight regain more likely if the medication is stopped reduced functional strength and physical capacity, increased falls risk in older adults, reduced bone density, and the loss of the metabolic benefits that muscle tissue provides including improved insulin sensitivity and glucose uptake

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Daniela Gamboa, who runs an integrated care/medical weight loss practice in Irving, Texas , agreed that when Ozempic or Wegovy is discontinued, the individuals appetite will increase back to baseline levels, making it harder to follow a lower-calorie diet to retain the weight loss

Pharma companies have been locked in legal battles against compounders, arguing the copies that they make are not safe