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Further, the PI3K/Akt/GSK-3 signaling pathway regulates mitochondrial complex I activity, which is essential for mitochondrial function, energy metabolism, and redox balance ( This study possesses distinct strengths and limitations

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Cannabinoid receptor 1 (CB1R) is one of the most prevalent G-protein coupled receptors (GPCRs) in the brain and plays a crucial role in synaptic and behavioral functions (Piomelli, 2025