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Following this pilot trial, etanercept was studied in a much larger, multicenter trial with 205 patients

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1b, was carefully chosen to align with the midline of the dorsal anterior cingulate cortex

Anti-anxiety effects in rats at 0.5 g/kg produced effects within 12 minutes including increased exploration time in open areas, while anti-aggression effects at same dose reduced physical attacks 5-fold within 12 minutes