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It is thought that bioactive peptides derived from whey proteins as a result of gastrointestinal digestion or bioactive peptides in the whey protein mixture with antioxidant properties may also play a role in improving liver and kidney damage caused by MTX

So, the liver takes time to metabolize it

IGF-1 can set the wheels in motion to increase aging by such blocking autophagy and stress resistance and increasing Reactive Oxygen species

25, 26 Owing to spatial compartmentalization, reaction kinetics and physiological functions of low ROS concentrations, the scavenging of ROS by cellular enzyme systems (for example, superoxide dismutase, catalase) is impaired