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The section below separates animal and human data, highlights reported reproductive benefits, and lists common clinical endpoints so clinicians and researchers can weigh the evidence
Tirzepatide is an investigational once-weekly GIPR/GLP-1R dualagonist 14 with a profound therapeutic superiority in reducing blood glucose and body weight beyond several approved drugs such as semaglutide 15 and dulaglutide 16 in multiple head-to-head clinical trials
Conversely, AAVs have a limited packaging size of ~5 kb with significantly milder inflammatory risk [143]
This review integrates molecular evolution, formulation advances, and biopharmaceutics modeling, including physiologically based biopharmaceutics modeling (PBBM), to illustrate emerging strategies shaping next-generation oral peptide therapeutics
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