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CaiTABCDE geneexpressing microbes consume l-carnitine, but only make TMA in the presence of E

Results from the study were consistent with global clinical data across safety, tolerability, PK, and pharmacodynamic measures, supporting the future development of elecoglipron, whereby China could be incorporated into the global Phase 3 program pending relevant regulatory approval

The mechanism of bacterial resistance and potential bacteriostatic strategies

Given that cyanide exposure from linamarin is strongly associated with the development of konzo, an increase in plasma oxidative stress may also affect cyanide action or metabolism, potentially amplifying its capacity to induce mitochondrial stress or giving rise to its oxidized form cyanate, which is a strong neurotoxin in various experimental models that can further decrease glutathione levels in the CNS 52,53