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Likewise, along with previous beneficial effect of BPC 157 in gastrointestinal tract, and inflammatory bowel disease complications that were accordingly solved (10, 11), poor healing of the fistulas (35), unhealed intestinal anastomosis (42, 43), massive intestinal resection leading to short bowel (43)) this study shows BPC 157's high potential to heal colon-colon anastomosis along with cysteamine colitis, thus, potential to counteract the consequences of the anastomosis for cysteamine colitis, and vice versa, convalescing the increased healing failure of anastomosis healing due to concomitant presentation of severe colitis

Timshel, P

metabolite Ac-LKKTE identified as potentially more active than parent compound Paradoxical finding: Both peptides show biological effects persisting hours to days after administration despite rapid plasma clearance Possible explanations: Tissue retention, active metabolites, or persistent signaling cascade activation Excretion Pathways Limited data exists on excretion for both peptides[22]: Likely renal elimination of peptide fragments Hepatic metabolism may contribute to clearance No accumulation detected in chronic dosing studies (animal models) Combined excretion kinetics have not been characterized in any species The disconnect between short plasma half-lives and prolonged biological effects represents a key area requiring mechanistic clarification for both individual peptides and their combination

Reference Links Gwyer, D., Wragg, N