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Within the nucleus, NRF2 binds to promoter regions of target genes which contain antioxidant response element (ARE) sequences, ultimately inducing the transcription of cytoprotective genes, i.e., those encoding for phase II detoxification enzymes and antioxidants

These findings demonstrate that the aqueous humor profile of our identified metabolites reflects the characteristics of eyes with glaucoma and that these metabolites have the potential to support the diagnosis of glaucoma