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Both are approved and licensed for use in the UK, though the Wegovy injection has been around for longer

Early weight loss at week 20 did not predict later cardiovascular benefits (HR 0.95), suggesting that semaglutides heart-protective effects may work through mechanisms independent of blood sugar control

Since unilateral T-RDN and bilateral A-RDN had comparable effects on GLP-1 mediated hemodynamic changes, it is possible that unilateral interruption of renal afferent input (limited input) to the central nervous system is sufficient to reduce sympathetic outflow affecting GLP-1 mediated hemodynamic changes

In Australia, the permitted indications include support of nervous system health and function [9]