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The body mass index (BMI) is commonly used to classify obesity (Table 1)

A gut-focused plan may include: digestive health assessment gut microbiome support probiotics or prebiotics when appropriate digestive enzymes DAO support in selected patients broader gut-healing measures Why this matters: poor digestion can increase symptom sensitivity gut inflammation may affect histamine handling dysbiosis may contribute to immune reactivity a damaged intestinal environment can make food responses harder to control That is one reason mast cell care often overlaps with work on reflux, bloating, cramping, food reactivity, diarrhea, and post-meal symptoms

In particular, the melatonin peak is associated with the nadir in body temperature, together with maximum tiredness, lowest alertness and performance (59) (Figure 6)

Lifestyle Habits Sun exposure, smoking, alcohol, and poor sleep can counteract glutathiones benefits