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Description

Neuropharmacology 86 , 241258 (2014)

In attempts to prolong the half-life of GLP-1 and develop a suitable compound for therapeutic use, some pharmaceutical companies (32) chose to optimize the exendin-4 peptide (a naturally occurring peptide obtained from Heloderma lizard venom, with 53% homology to human GLP-1), which leads to an intravenous half-life of ~30 min (3335)

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Rotating injection sites helps prevent localized tissue reactions and lipohypertrophy, a thickening of fatty tissue that can occur from repeated injections in the same spot