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My recommendation is to stay on the lower end of these recommendations for two reasons: #1

In this trial, once-weekly cagrilintide-semaglutide for 68 weeks in adults with overweight or obesity was highly effective and led to substantial and clinically meaningful weight loss, the authors concluded

Women who are pregnant or breastfeeding should discontinue use and consult their healthcare provider for safe alternatives

Int Immunopharmacol 72:445453 Lin X et al (2020) Ameliorate effect of Pyrroloquinoline quinone against cyclophosphamide-induced nephrotoxicity by activating the Nrf2 pathway and inhibiting the NLRP3 pathway