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The amide group of sitagliptin occupies the S 2 pocket, creating a salt bridge with Glu205 and Glu206

However, the percentage of these molecules is low, such that large amounts of glutathione need to be ingested in order for supplementation to have any meaningful effect

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Mechanisms include: Restoration of endothelial nitric oxide synthase (eNOS) Upregulation of VEGF and FGF-2 (fibroblast growth factor 2) Reduction of oxidative stress and cytokine-induced apoptosis BPC-157 preserved endothelium-dependent vasodilation via upregulation of eNOS and suppression of vascular inflammation. Gwyer Findlay et al., Peptides 4