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GLP-1 receptor agonists and GLP-1 and glucose-dependent insulinotropic peptide agonists have several mechanisms of action, including reduction of gastric emptying, inhibition of glucagon secretion, beneficial changes in the intestinal microbiome, and direct effects on hypothalamic nuclei to enhance satiety (which promotes weight loss)

When starting carnitine, as with any supplement, its best to start with a low dose and increase slowly to assess tolerance

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This personalization prevents the trial-and-error cycle that leads patients to skip doses or change timing on their own