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However, these studies were performed in culture with human umbilical vein endothelial cells from non-vapers, such that more physiologic follow-up studies are needed

Conjugating TEM8-targeting antibodies with cytotoxic monomethyl auristatin E was successful in specifically directing the drug to the tumor microenvironment of orthotopic tumors and patient derived xenografts, significantly inducing regression or eradication of tumor growth in pre-clinical models [323]