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In one human study, some of the reported side effects of chanca piedra supplementation included: abdominal pain painful urination blood in the urine nausea Abdominal pain was by far the most common, with the others being much less commonly reported ( Chanca piedra may also reduce blood sugar and blood pressure levels, so it should be used with caution if youre on a blood pressure or blood sugar lowering medication ( Keep in mind that supplements arent regulated by any government organizations, so theres little oversight to ensure that the label is an honest representation of whats in the supplement