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For the cause that chemical coordination of metal ions is indispensable for normal hydrolytic activities of phospholipases and metalloproteases, secondary metabolites capable of disrupting the enzyme-metal ion bondage inhibits enzymatic progression [166]
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Cigarettes were the most commonly used commercial tobacco product (21.6%), followed by cigars (6.2%), smokeless tobacco (5.2%), roll-your-own tobacco (3.0%), and pipes (1.5%)
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