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Orforglipron's demonstration that a small molecule could achieve clinically relevant GLP-1 receptor activation upended this assumption and opened a new chapter in incretin-based therapeutics

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Research shows that weight loss and improved metabolic health can boost confidence, self-image and sexual self-esteem, which for many patients enhances rather than diminishes desire. Dix noted that because GLPs affect the reward areas of the brain, they are believed to reduce compulsive behaviours

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