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The FDA has documented significant safety concerns around tirzepatide dosing mistakes , people doubling doses, escalating too quickly, or using off-label amounts

Joint pain affects over 95% of patients and typically appears symmetrically (both hands, both knees), while skin manifestations range from the butterfly rash of lupus to hyperelastic skin that stretches beyond normal limits

Optimal encapsulation was observed at a drug-to-vesicle mass ratio of 1:10, achieving an 81% encapsulation efficiency and a drug loading of 7.8%

This concern is particularly relevant for patients with stricturing CD, in whom up to 50% develop fibrostenotic complications within 10 years of diagnosis (74)