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Musso, G., Cassader, M., Paschetta, E

The two RENEW-ALC trials (combined enrollment: 2,200 patients) began recruiting in late 2025, with primary completion expected in 2028 the largest Phase 3 trials of any GLP-1 agent for addiction

GLP-1 receptors exist throughout the brain in the hypothalamus, which controls appetite, and in the mesolimbic reward system, the same circuitry involved in addiction and compulsive behavior