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These sequences overlap with known ABI5 binding sites, suggesting that ABI5 may regulate their transcription by directly binding to these regions

In OA research, recent evidence indicates that pharmacological activation of the Nrf2GPX4 signaling axis using bioactive natural products or synthetic small molecule agonists can effectively mitigate ferroptosis in vitro cultured chondrocytes and in vivo OA animal models, while significantly suppressing ECM degradation progression (Zhang Z

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Competing Interests Blair Suter, Allison Bigeh, Timothy Frommeyer, and Laxmi Mehta declare that they have no conflicts of interest