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Exposure to sugars induces rapid GLP-1 secretion from T1R3-sensitive cells, following a dose-dependent pattern where higher stimulus concentrations lead to greater secretionan effect blocked by GLP-1 receptor antagonists ( 5.3 Clinical evidence regarding GLP-1 and taste In the past few years, there has been growing evidence that highlights the physiological and molecular mechanisms in which GLP-1 regulates taste perception

The SURPASS-3 study was started to study the efficacy and safety of TZP versus basal insulin degludec in diabetic patients inadequately controlled by metformin with or without an SGLT2-i for 52 weeks (7274)

doi: 10.1038/s41598-019-55821-4 53

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