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However, satellite cells can also be robustly activated upon tissue injury, after which they undergo symmetric divisions to generate new stem cells and numerous proliferating myoblasts that later differentiate to muscle cells (myocytes) to rebuild the muscle fibre, thereby supporting skeletal muscle regeneration

Each subgroup included three to five animals

For antagonist assays, the cells were pre-treated for 30 min with a relacorilant concentration gradient prior to the addition of 100 nM (EC max ) dexamethasone and incubated for 24 h (0.2% final DMSO)

Brown E, Wilding JPH, Barber TM, Alam U, Cuthbertson DJ (2019) Weight loss variability with SGLT2 inhibitors and GLP-1 receptor agonists in type 2 diabetes mellitus and obesity: mechanistic possibilities