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In addition, ALCAR had no effect on the expression of the nerve growth factor receptors on SKOV-3 or OVCAR-3 ovarian cancer cells [1]

As a widely used antihypertensive drug, losartan enhances vascular perfusion, thereby enhancing drug delivery and intratumoral invasion of immune effector cells and, on the other hand, enhances chemotherapy sensitivity by inhibiting IGF-1 signaling to reshape ovarian cancer and the microenvironment (140)