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Administering UA to adult rats either 24 h before middle cerebral artery occlusion (62.5 mg/kg, intraperitoneally) or 1 h after reperfusion (16 mg/kg, intravenously) can protect cultured hippocampal neurons from cell death induced by brain ischemia-related damage, including exposure to excitatory amino acids, glutamate, and the metabolic poison cyanide [139]

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Recent funding from the Congressionally Directed Medical Research Program will support a multi-site study that should kick off by the end of the year, and Schacht suspects approval of a GLP-1 drug for AUD in less than three years