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This mechanism converges with the previously detailed inflammatory mechanisms, particularly those mediated by pro-inflammatory cytokines, and the increase in adiposity, representing a shared pathological link between metabolic dysfunction and skeletal muscle impairment

Mast cells (MCs) are stimulated and degranulate, releasing histamine, IL-6, IL-8, prostaglandin D2 and tumor necrosis factor-alpha (TNF)- together with IL-23 and IL-31 and other cytokines (48, 49)

Dose calculation errors are the second most common protocol failure: always label reconstituted vials with final concentration (mg/ml), reconstitution date, and 28-day expiration to prevent administration mistakes

Both medicines also influence lipid metabolism and visceral fat