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doi: 10.1530/acta.0.1290322 107 BermanBDuncanMR

The accumulation of -Syn in excess also activates the autophagy-lysosomal pathway (Zhang et al., 2018), mutations in -Syn proteins undergo misfolding in transcription-translation to produce toxicity, and defective mitophagy further exacerbates neurotoxicity, leading to neuronal loss or damage (Wang et al., 2018)

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Some practitioners use compounded formulations at customized doses to allow finer titration increments, supporting tolerability optimization during the adaptation phase