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For all models, we used diagnostic plots (residuals vs fitted and qqplot) to examine assumptions of normality and homogeneity of variances, and we tested uniformity and dispersion of the residuals using the DHARMa package 54

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Example: In vitro nephrotoxicity screening The model has been used to evaluate other compounds, and it correctly classified four of six true positives and two of three true negatives, demonstrating the validity of the in vitro nephrotoxicity model for detecting tubular toxicants