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Major pharmaceutical companies, including Novo Nordisk, Sanofi, Eli Lily, Janssen and Merck are currently developing their own GLP-1/glucagon co-agonist candidates, most of which are in Phase 1 or Phase 2 clinical trials [225]

Factors that affect TLS risk include tumor type (particularly hematologic malignancies), specific tumor characteristics (eg, bulky tumor, high cellular proliferation rate), and baseline creatinine (Wilson 2012)

From Diabetes to Oncology: Glucagon-like Peptide-1 (GLP-1) Receptor Agonists Dual Role in Prostate Cancer

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