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Quick Answer If semaglutide isn't producing weight loss results, the seven most common reasons are: (1) dose not optimized, (2) body has adapted (tolerance/plateau), (3) hidden hormonal resistance (thyroid, insulin, cortisol), (4) stress and poor sleep, (5) nutrition quality issues, (6) muscle loss and low activity, and (7) underlying medical conditions or interfering medications

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Stimulants such as amphetamines or methylphenidate can interact with Bupropion SR to raise blood pressure and heart rate, increasing cardiovascular risk