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Rapid improvement in blood glucose control may temporarily worsen diabetic retinopathy, particularly in patients with pre-existing retinopathy or on insulin therapy

instead, it transitions into a state of persistent, unremitting chronic inflammation

Men with pre-existing symptoms suggestive of hypogonadismincluding persistent fatigue, reduced libido, erectile dysfunction, decreased muscle mass, or depressed moodshould undergo testosterone evaluation before initiating semaglutide

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