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When compared to dulaglutide or the placebo, tirzepatide dose-dependently decreased triglyceride, serum lipoprotein profile, apolipoprotein (apo) C-III, and apo B levels over time

Although the mechanisms are not yet fully understood, rodent and human studies show that GIP plays a role in the regulation of lipolysis and lipogenesis in adipose tissue, which could contribute to improved lipid homeostasis and whole body energy metabolism [23, 24]

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What sets this review apart is its focus on the translational dimension: highlighting recent advances in delivery systems to overcome bioavailability challenges and identifying gaps that must be addressed through clinical research