2023;6(5) doi: 10.1001/jamanetworkopen.2023.14493
, 104 , 29-41, doi: Hiyama, N., Ando, T., Maemura, K., Sakatani, T., Amano, Y., Watanabe, K., Kage, H., Yatomi, Y., Nagase, T., Nakajima, J., and Takai, D
This is why crow's feet require both structural collagen rebuilding (GHK-Cu) AND muscular relaxation (SNAP-8/Syn-Ake) for comprehensive treatment addressing the collagen deficit alone doesn't stop the muscle from continuing to crease it, and addressing the muscle alone doesn't repair the existing structural damage
Factor #1: Weight loss restores ovulation (sometimes very quickly) The mechanism works like this: Excess body fat produces estrogen and disrupts normal ovulation, while fat cells also produce inflammatory compounds that interfere with reproductive hormones