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In addition to stimulating the increase of eosinophils, neutrophils, mast cells, and macrophages (red box), CS can also combine with RAGE to further stimulate the expression of IL-33, gradually aggravating airway remodeling

Conducted in 37 healthcare institutions across six countries in Asia and Europe, the studys results demonstrated that: Switching was associated with favorable differences in BoPH related to biological pathways impacted by cigarette smoke (inflammation, oxidative stress, oxygen transport, genotoxicity, lipid metabolism, endothelial function, and blood clotting potential), as well as better cardiovascular and respiratory function compared with current smokers