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At the 24-week mark, the mean increases in heart rate were: 1 mg dose: +4.1 bpm 4 mg dose: +6.1 bpm 8 mg dose: +7.9 bpm 12 mg dose: +7.8 bpm These increases were observed to be maximal around 24 weeks and then showed a slight attenuation, though they remained elevated above baseline for the entire 48-week study period

While lifestyle modifications remain the foundation of any weight management program, medical science has developed supportive treatments to help address the biological factors that make weight loss difficult

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