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At the same time, cigarette smoking activates MAPKs in the lung, increasing the number of neutrophil granulocytes, lymphocytes, macrophages, and other cells, and inducing cells to release pro-inflammatory factors and chemokines in Figure 1 (Marumo et al., 2014

Keywords and combination of keywords were used to search the electronic databases and were organized following the population intervention comparison outcome (PICO) model (Fig

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