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seek urgent medical advice for right upper quadrant pain or jaundice Diabetic retinopathy complications : Patients with pre-existing retinopathy should have regular ophthalmological monitoring, as rapid glycaemic improvement may temporarily worsen retinal disease Renal impairment : Dehydration from gastrointestinal side effects can affect kidney function, particularly in vulnerable patients Injection site reactions (redness, itching, bruising) are common but usually mild

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[DOI] [PMC free article] [PubMed] [Google Scholar] 76.Hinnen D

Moreover, Epac2 engages Ras-related protein 1 (Rap1) and phospholipase C (PLC), thereby elevating inositol triphosphate (IP3) and diacylglycerol (DAG) levels