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Adipogenesis In contrast to their promotive effects on osteogenesis, GLP-1 and its analogues GLP-1(9-36), GLP-1(7-36) and Liraglutide demonstrated a dose-dependent inhibition of adipogenic differentiation in hASCs

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The lactam bridge between Asp and Lys constrains the molecule into the bioactive -turn conformation that drives non-selective agonism across MC1R, MC3R, MC4R and MC5R