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One possible reason for maintaining hyperoxidation sensitivity is that hyperoxidized peroxiredoxins serve specific functions within the cell, for example, recruitment of chaperones to protein aggregates (Hanzen et al , 2016) or prevention of excessive oxidation of important cellular redox couples and therefore maintenance of cell viability, as shown in this study and in others (Day et al , 2012

BMJ 2012;344.

The chemical diversity of these compounds is large, and little is known about the biological function of the different stereochemistries