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We proposed that the lysosomal membrane itself might be the missing link that orchestrates the AND gate and compensates for the more-than-two orders of magnitude in concentration needed for RHEBGTP activation of mTORC1
Rates and mechanisms of fluid and electrolyte transport vary along the length of the gut and are influenced by the relative permeability of the gut barrier and transport processes at the different anatomical locations 11
Animal studies demonstrate significant reductions in body weight and adiposity, with metabolic improvements occurring through enhanced fat oxidation and improved metabolic efficiency
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