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When freeze-drying is performed without a protective matrix (such as sucrose or mannitol), residual bound water may cause collapse during the final drying stage

10 Goschorska, M., Gutowska, I., Baranowska-Bosiacka, I., Barczak, K

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Because crystalline formulations are better absorbed than naturally occurring vitamin B 12 , patients older than 50 years and strict vegetarians should consume foods fortified with vitamin B 12 and vitamin B 12 supplements, rather than attempting to get vitamin B 12 strictly from dietary sources