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Sustained, gradual loss is typical and healthier

Low levels should alert to the possibility of adrenal insufficiency

Food preferences may shift, with some individuals experiencing reduced cravings for high-fat or high-sugar foods

Saunders takes a similarly cautious strategy with her patients: When our patients are off medication for an extended period, we generally recommend starting back at the lowest dose and titrating up gradually. The more doses a person has missed, the more likely they are to have difficulty tolerating the medication when they restart it, and the more likely they are to have gastrointestinal side effects, Low Wang says