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Severe symptoms requiring immediate medical attention include inability to urinate for 8+ hours, severe dizziness, confusion, rapid breathing, sunken eyes, extreme fatigue, and inability to keep fluids down for 12+ hours

So long as water at the point of consumption tests at safe levels for unhealthy contaminants, pH is not generally a matter of concern

Specifically, the effect allele encodes for leucine, which is more hydrophobic than the reference proline allele and may therefore increase stability of the hydrophobic region of the signal peptide (Supplementary Information)

That means there are 40 parts myo-inositol to 1 part d-chiro-inositol