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Statistical analyses As Pearson correlation coefficients between the nine metabolite concentration values (three metabolites in three voxels) were substantial even after adjustment for potential confounders, we used principal component analysis (PCA) to identify latent metabolite variables, and extracted scores for each component (see Results and SA7 for details)

Many individuals describe a sense of calm returning to their body within days or weeks as inflammation begins to subside and energy improves

In recent years, the influence of stress on the development and course of HT has also been investigated