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After binding to ACE2 and/or NRP1 receptors, the S-protein is proteolytically pre-activated by human proprotein convertase furin 66

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employed molecular docking and ion resonance biosensors to illustrate the strong binding affinity between PDGFR- and SalB , and SalB relieves HF by inhibiting the PDGFR- signaling pathway and inducing HSC apoptosis, and inflammatory reaction of HSC (Liu et al., 2023b)