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By percentage, the fat mass loss was 15.6 10.1%, and the muscle mass loss was 4.8 4.4%, which was statistically significant

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Important safety considerations include risk of pancreatitis (treatment should be discontinued if suspected), gallbladder disease, and potential worsening of diabetic retinopathy in patients with pre-existing retinopathy who experience rapid improvement in glucose control (particularly with semaglutide)

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