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Known hypersensitivity to tirzepatide or any formulation component (including niacinamide in the compounded version) also contraindicates use

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They work by mimicking the GLP-1 hormone, which: Stimulates insulin secretion in a glucose-dependent manner Suppresses glucagon release Slows gastric emptying Reduces appetite by acting on receptors in the brain It is important to note that Wegovy (semaglutide 2.4 mg) is the formulation licensed for weight management in the UK